gBOIN: A Unified Model-Assisted Phase I Trial Design Accounting

We propose a generalized Bayesian optimal interval design, gBOIN, that accommodates various existing toxicity grade scoring systems coloktoto under a unified framework. May 13, 2022 This paper proposes the generalized Bayesian optimal interval design for dose-finding accounting for efficacy playwin77 and colaslot toxicity grades. The new  Dec 13, 2021 We propose an adaptive generalized Bayesian optimal interval design with shrinkage boundaries, gBOINS, which can account for continuous, toxicity grades  May 13, 2022 The new design, named “gBOIN-ET” design, is model-assisted, simple, and straightforward to implement in actual oncology dose-finding trials than  Dec 3, 2021 We propose a time-to-event Bayesian optimal interval design to accelerate the dose-finding process utilizing toxicity grades based on both cumulative bocor777 and

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